Select Original Research

A Transcriptional Enhancer Regulates Cardiac Maturation

Htet M, Lei S, Bajpayi S, Gangrade H, Arvantis M, Zoitou A, Murphy S, Chen EZ, Koleni N, Lin BL, Kwon C, Tampakakis E

Nature Cardiovascular Research 2024

Trajectory Reconstruction Identifies Dysregulation of Perinatal Maturation Programs in Pluripotent Stem Cell-Derived Cardiomyocytes

Kannan S, Miyamoto M, Zhu R, Lynott M, Guo J, Chen EZ, Colas AR, Lin BL, Kwon C

Cell Reports 2023

Conserved Transcription Factors Promote Cell Fate Stability and Restrict Reprogramming Potential in Differentiated Cells

Missinato M, Murphy S, Lynott M, Yu MS, Kervadec A, Chang YL, Kannan S, Loreti M, Lee C, Amatya P, Tanaka H, Huang CT, Puri PL, Kwon C, Adams PD, Qian L, Sacco A, Andersen P, Colas AR

Nature Communications 2023

Cardiac Progenitors Instruct Second Heart Field Fate through Wnts

Miyamoto M, Kannan S, Anderson MJ, Liu X, Suh D, Htet M, Li Biyi, Kakani T, Murphy S, Tampakakis E, Lewandoski M, Andersen P, Uosaki H, Kwon C

PNAS 2023

Human Pluripotent Stem Cell-Derived Myogenic Progenitors Undergo Maturation to Quiescent Satellite Cells upon Engraftment

Sun C, Kannan S, Choi IY, Lim H, Zhang H, Chen GS, Zhang N, Park SH, Serra C, Iyer SR, Lloyd TE, Kwon C, Lovering RM, Lim SB, Andersen P, Wagner KR, Lee G

Cell Stem Cell 2022

Heart Neurons Use Clock Genes to Control Myocyte Proliferation

Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy SA, Lin BL, Liu T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G, Minichiello L, Kwon C

Science Advances 2021

Transcriptomic Entropy Benchmarks Stem Cell-Derived Cardiomyocyte Maturation against Endogenous Tissue at Single Cell Level

Kannan S, Farid M, Lin BL, Miyamoto M, Kwon C

PLoS Computational Biology w/ reviews from Review Commons 2021

PGC1/PPAR Drive Cardiomyocyte Maturation at Single Cell Level via YAP1 and SF3B2

Murphy SA, Miyamoto M, Kervadec A, Kannan S, Tampakakis E, Kambhampati S, Lin BL, Paek S, Andersen P, Lee DI, Zhu R, An SS, Kass DA, Uosaki H, Colas AR, Kwon C

Nature Communications 2021

Exercise Triggers CAPN1-Mediated AIF Truncation, Inducing Myocyte Cell Death in Arrhythmogenic Cardiomyopathy

Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-Codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O'Rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N

Science Translational Medicine 2021

Capturing Cardiogenesis in Gastruloids

Rossi G, Broguiere N, Miyamoto M, Boni A, Guiet R, Girgin M, Kelly RG, Kwon C, Lutolf MP

Cell Stem Cell 2020

Large Particle Fluorescence-Activated Cell Sorting Enables High Quality Single Cell RNA-Sequencing and Functional Analysis of Adult Cardiomyocytes

Kannan S, Miyamoto M, Lin B, Zhu R, Murphy S, Kass D, Andersen P, Kwon C

Circulation Research 2019

Precardiac Organoids Form Two Heart Fields via Bmp/Wnt Signaling

Andersen P, Tampakakis E, Jimenez DV, Kannan S, Miyamoto M, Shin HK, Saberi A, Murphy S, Sulistio E, Chelko SP, Kwon C

Nature Communications 2018

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

Sadahiro T, Isomi M, Muraoka N, Kojima H, Haginiwa S, Kurotsu S, Tamura F, Tani H, Tohyama S, Fujita J, Miyoshi H, Kawamura Y, Goshima N, Iwasaki YW, Murano K, Saito K, Oda M, Andersen P, Kwon C, Uosaki H, Nishizono H, Fukuda K, Ieda M

Cell Stem Cell 2018

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

Cho GS, Lee DI, Tampakakis E, Murphy S, Andersen P, Uosaki H, Chelko S, Chakir K, Hong I, Seo K, Chen HV, Chen X, Basso C, Houser SR, Tomaselli GF, O'Rourke B, Judge DP, Kass DA*, Kwon C*

Cell Reports 2017

Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons

Oh Y, Cho GS, Li Z, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C*, Lee G*

Cell Stem Cell 2016

Transcriptional Landscape of Cardiomyocyte Maturation

Uosaki H, Cahan P, Lee DI, Wang S, Miyamoto M, Fernandez L, Kass DA, Kwon C

Cell Reports 2015

Phosphodiesterase 9A Controls Nitric-Oxide-Independent cGMP and Hypertrophic Heart Disease

Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA

Nature 2015

Precardiac Deletion of Numb and Numblike Reveals Renewal of Cardiac Progenitors

Shenje LT, Andersen P, Uosaki H, Fernandez L, Rainer PP, Cho GS, Lee DI, Zhong W, Harvey RP, Kass DA, Kwon C

eLife 2014

Mutations in Alström Protein Impair Terminal Differentiation of Cardiomyocytes

Shenje LT, Andersen P, Halushka MK, Lui C, Fernandez L, Collin GB, Amat-Alarcon N, Meschino W, Cutz E, Chang K, Yonescu R, Batista DA, Chen Y, Chelko S, Crosson JE, Scheel J, Vricella L, Craig BD, Marosy BA, Mohr DW, Hetrick KN, Romm JM, Scott AF, Valle D, Naggert JK, Kwon C, Doheny KF, Judge DP

Nature Communications 2014